周媛媛, 王进, 陈维, 缪雨季. 2017—2022年某省级疾控中心参加全国生物剂量估算能力比对结果分析[J]. 职业卫生与应急救援, 2024, 42(5): 620-623. DOI: 10.16369/j.oher.issn.1007-1326.2024.05.011
引用本文: 周媛媛, 王进, 陈维, 缪雨季. 2017—2022年某省级疾控中心参加全国生物剂量估算能力比对结果分析[J]. 职业卫生与应急救援, 2024, 42(5): 620-623. DOI: 10.16369/j.oher.issn.1007-1326.2024.05.011
ZHOU Yuanyuan, WANG Jin, CHEN Wei, MIAO Yuji. Analysis of a provincial CDC’s results in the comparison of national biological dose estimation capability from 2017 to 2022[J]. Occupational Health and Emergency Rescue, 2024, 42(5): 620-623. DOI: 10.16369/j.oher.issn.1007-1326.2024.05.011
Citation: ZHOU Yuanyuan, WANG Jin, CHEN Wei, MIAO Yuji. Analysis of a provincial CDC’s results in the comparison of national biological dose estimation capability from 2017 to 2022[J]. Occupational Health and Emergency Rescue, 2024, 42(5): 620-623. DOI: 10.16369/j.oher.issn.1007-1326.2024.05.011

2017—2022年某省级疾控中心参加全国生物剂量估算能力比对结果分析

Analysis of a provincial CDC’s results in the comparison of national biological dose estimation capability from 2017 to 2022

  • 摘要:

    目的 通过分析某省级疾控中心参加全国生物剂量估算能力比对结果及偏差原因,进一步提高实验室核与辐射突发事件卫生应急中的生物剂量估算能力。

    方法 回顾性收集某省级疾病预防控制中心放射生物实验室2017—2022年参加全国生物剂量估算能力比对的材料,整理每个样本的外周血淋巴细胞染色体畸变分析细胞数、双着丝粒体(dicentric,dic) + 着丝粒环(ring,r)畸变细胞率、dic + r畸变率,分析考核样本估算值和照射值的相对偏差。2017年—2021年比对采用GB/T 28236—2011中剂量-效应曲线估算剂量值;2022年比对采用该省级疾控中心自建立的剂量-效应曲线。

    结果 2017—2022年12个生物剂量考核样本100%合格,相对偏差均 ≤ 20%,其中相对偏差 ≤ 5%的4个,占33.3%。8个样本剂量估算值低于实际照射值,占66.7%。通过该中心实验室的剂量-效应曲线估算的剂量均值为(2.16±1.26)Gy;GB/T 28236—2011推荐曲线估算的剂量均值为(2.15 ± 1.26)Gy,两者差异无统计学意义(P > 0.05)。

    结论 染色体标本制备的质量和技术人员经验是影响生物剂量估算质量的两个重要因素。提高染色体标本制备的质量水平,加强实验室技术人员识别染色体畸变指标的能力,可提高核与辐射突发事件卫生应急中人员生物剂量估算的准确性。

     

    Abstract:

    Objective To improve the biological dose estimation capability in responding to nuclear and radiation emergencies by analyzing the results and deviation causes from a provincial CDC’s laboratory participating in the national biological dose estimation capability assessment.

    Methods The data of a provincial center for disease control and prevention’s radiological biology laboratory participating in the national biological dose estimation capability assessment from 2017 to 2022 were retrospectively collected. The number of cells analyzed for chromosomal aberrations, the rate of dicentric (dic) and ring (r) chromosome aberrations, and the rate of dic+r aberrations in peripheral blood lymphocytes of each sample were sorted out. The relative deviation between the estimated value and the irradiation dose of the assessed samples was analyzed. From 2017 to 2021, the dose was estimated using the dose-response curve in GB/T 28236-2011. In 2022, the dose was estimated using the dose-response curve established by the provincial CDC itself.

    Results All 12 biological dose assessment samples from 2017 to 2022 were 100% qualified, with relative deviations all ≤ 20%, among which 4 samples had relative deviations ≤ 5%, accounting for 33.3%. The estimated doses of 8 samples were lower than the actual irradiation dose, accounting for 66.7%. The average dose estimated by the dose-response curve of the laboratory was (2.16 ± 1.26) Gy, while the average dose estimated by the dose-response curve recommended in GB/T 28236-2011 was (2.15 ± 1.26) Gy, and there was no statistically significant difference between these two standard curves (P > 0.05).

    Conclusions The quality of chromosome specimen preparation and the experience of technical personnel are two important factors affecting the quality of biological dose estimation. Improving the quality of chromosome specimen preparation and strengthening the ability of laboratory technicians to identify chromosomal aberration indicators can improve the accuracy of biological dose estimation for personnel in nuclear and radiation emergencies.

     

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