Abstract: Objective To explore the practical application of digital supervision technology in occupational health supervision and provide a scientific basis for improving regional occupational health supervision efficiency. Methods The informatization data resources related to occupational health management in the Pudong New Area of Shanghai were collected and analyzed. An intelligent supervision system for occupational health was established in Pudong, and its application was evaluated with optimization suggestions proposed. Results A total of 201 279 pieces of informatization data were obtained from five information systems at the national, Shanghai municipal, and Pudong New Area levels, as well as from monitoring reports. Among these, the application quality of occupational health-related professional data was higher than that in other fields. The intelligent occupational health supervision system included a basic database of occupational health management entities, a basic task database for occupational health supervision, and a comprehensive supervision and response module. After implementing the system, the problem discovery rate during occupational health inspections was higher than before (P < 0.05). Conclusions The application of digital supervision technology contributed to improving the efficiency of occupational health supervision. However, challenges remain, such as data silos, varying quality of multi-source data, insufficient reliability of model algorithms, and low acceptance of digital supervision by employers. It is recommended that government departments optimize data management policies and further promote data openness and sharing. Data standardization should be implemented alongside system construction, and management models should be continuously refined. Additionally, efforts should be made to increase awareness and application of digital supervision technologies and systems to boost employers’ engagement in self-compliance management.