Abstract: Objective To provide an effective and reliable in vitro evaluation method for skin corrosion induced by chemicals. Methods EpiSkin^TM reconstructed human epidermis model was used to classify chemical substances with known classification categories and unknown classification categories,and to evaluate the applicability of EpiSkin^TM in skin corrosion induced by chemicals. Results In corrosion test,dichloroacetyl chloride was identified as 1A, glyoxylic acid monohydrate was identified as 1B/1C,which were consistent with the known classification. The other two unknown-classification substances were classified as non-corrosive and 1B/1C, respectively. Conclusion The in vitro testing method using EpiSkin^TM reconstructed human epidermis model is suitable for classification and evaluation of skin corrosion induced by chemicals.