黄红英, 冯文艇, 吴子俊, 翁少凡, 周金鹏, 李智民. 男性电焊作业人员体液免疫和性激素水平的调查研究[J]. 职业卫生与应急救援, 2017, 35(3): 216-218. DOI: 10.16369/j.oher.issn.1007-1326.2017.03.006
引用本文: 黄红英, 冯文艇, 吴子俊, 翁少凡, 周金鹏, 李智民. 男性电焊作业人员体液免疫和性激素水平的调查研究[J]. 职业卫生与应急救援, 2017, 35(3): 216-218. DOI: 10.16369/j.oher.issn.1007-1326.2017.03.006
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HUANG Hongying, FENG Wenting, WU Zijun, WENG Shaofan, ZHOU Jinpeng, LI Zhimin. Serum immunoglobulin and gonadal hormone levels of male welders[J]. Occupational Health and Emergency Rescue, 2017, 35(3): 216-218. DOI: 10.16369/j.oher.issn.1007-1326.2017.03.006
Citation: HUANG Hongying, FENG Wenting, WU Zijun, WENG Shaofan, ZHOU Jinpeng, LI Zhimin. Serum immunoglobulin and gonadal hormone levels of male welders[J]. Occupational Health and Emergency Rescue, 2017, 35(3): 216-218. DOI: 10.16369/j.oher.issn.1007-1326.2017.03.006
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男性电焊作业人员体液免疫和性激素水平的调查研究

Serum immunoglobulin and gonadal hormone levels of male welders

    摘要
  • 摘要:
    目的  分析焊工作业中锰接触对作业人员血清免疫球蛋白和性激素的影响。
    方法  2016年10月以某人防工程公司96名男性焊工为焊工组, 同时选择96名男性非焊工人员作为对照组, 以全自动生化仪检测两组人员的血清免疫球蛋白IgA、IgM、IgG水平, 以石墨炉原子吸收法检测两组人员的尿锰水平; 以化学发光免疫分析法检测促黄体生成激素(LH)、促卵泡生成激素(FSH)、睾酮(T)、黄体酮(P)、雌二醇(E2)和泌乳素(PRL), 并对结果进行分析。
    结果  焊工组尿锰水平为(1.59 ±0.67)μg/L, 高于对照组的(0.45 ±0.08)μg/L, 差异有统计学意义(P < 0.01)。焊工组的血清IgG、T和P水平低于对照组, FSH水平高于对照组, 差异有统计学意义(P < 0.05或0.01)。焊工组的IgA与T水平呈负相关(r=-0.271, P < 0.05), IgM和E2、尿锰, 尿锰和FSH、PRL均呈正相关(r=0.209、0.220、0.487、0.250, P < 0.01)。
    结论  电焊作业增加了锰接触的机会, 可能会降低作业人员的免疫能力并影响其内分泌系统。

     

    Abstract:
    Objective  To observe the adverse effect of occupational manganese exposure on humoral immunity and sex hormone of welders.
    Methods  Totally 96 male Welders and 96 workers without any exposure to occupational hazards were studied. The immunoglobulin(IgA, IgM and IgG) were measured with automatic biochemistry instrument. The urinary Mn was measured with graphite furnace atomic absorption spectrometry. Serum luteinizing hormone(LH), follicle stimulating hormone(FSH), testosterone(T), progesterone(P), estradiol(E2) and prolactin(PRL)were measured by radioimmuno assay.
    Results  The urinary manganese level of welders was (1.59 ±0.67)μg/L, which was significantly higher than that(0.45 ±0.08) μg/Lof non-exposed workers(P < 0.01). The serum levels of IgG, T and P of welders were lower than those of non-exposed workers, while FSH of welders was higher(P < 0.01 or 0.05). The Pearson correlation coefficient showed that serum levels of IgM, FSH and PRL were positively correlated with the urinary Mn level, respectively (r=0.220, 0.487, 0.250, P < 0.01). It showed that serum level of IgA was negatively correlated with T(r=-0.271, P < 0.01), and IgM was positively correlated with E2(r=0.209, P < 0.01).
    Conclusion The welding increases manganese exposure and furthermore may affect the immunity and endocrine system of welders.

     

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