葛欣, 盛荣建, 郭佳娣, 朱宝立, 程剑. hOGG1、APEX1和XRCC1基因单核苷酸多态性与噪声性听力损失的关联研究[J]. 职业卫生与应急救援, 2019, 37(2): 107-112. DOI: 10.16369/j.oher.issn.1007-1326.2019.02.002
引用本文: 葛欣, 盛荣建, 郭佳娣, 朱宝立, 程剑. hOGG1、APEX1和XRCC1基因单核苷酸多态性与噪声性听力损失的关联研究[J]. 职业卫生与应急救援, 2019, 37(2): 107-112. DOI: 10.16369/j.oher.issn.1007-1326.2019.02.002
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GE Xin, SHENG Rongjian, GUO Jiadi, ZHU Baoli, CHENG Jian. Single nucleotide polymorphisms of hOGG1, APEX1 and XRCC1 genes and their association with noise-induced hearing loss among noise-exposed workers[J]. Occupational Health and Emergency Rescue, 2019, 37(2): 107-112. DOI: 10.16369/j.oher.issn.1007-1326.2019.02.002
Citation: GE Xin, SHENG Rongjian, GUO Jiadi, ZHU Baoli, CHENG Jian. Single nucleotide polymorphisms of hOGG1, APEX1 and XRCC1 genes and their association with noise-induced hearing loss among noise-exposed workers[J]. Occupational Health and Emergency Rescue, 2019, 37(2): 107-112. DOI: 10.16369/j.oher.issn.1007-1326.2019.02.002
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hOGG1、APEX1和XRCC1基因单核苷酸多态性与噪声性听力损失的关联研究

Single nucleotide polymorphisms of hOGG1, APEX1 and XRCC1 genes and their association with noise-induced hearing loss among noise-exposed workers

    摘要
  • 摘要:
    目的 探讨人类8-羟基鸟嘌呤糖苷酶基因（hOGG1）、脱嘌呤脱嘧啶核酸内切酶1基因（APEX1）、X射线损伤修复交叉互补基因（XRCC1）多态性与中国汉族人群噪声性听力损失（noise-induced hearing loss，NIHL）的易感关联性。
    方法 以江苏省某化纤公司下属3个子公司接触噪声的作业工人为研究对象，结合工作场所噪声声级测量结果和工人纯音测听结果，筛选病例组585人和对照组619人。获取两组人群周围血基因组DNA，采用TaqMan探针法对所选基因的单核苷酸多态性位点进行基因分型。
    结果 共筛选3个候选基因：hOGG1、XRCC1和APEX1。logistic回归分析结果显示：在显性模型中，相比GG基因型，rs2072668 CC+CG基因型可能是噪声性听力损失发病的危险因素，其调整的OR值及95% CI值为1.40（1.10~1.78）；在90~95 dB（A）·年累积噪声暴露量下，相比GG基因型，rs2072668位点CC+CG基因型可能是噪声性听力损失发病的危险因素，其调整的OR值及95% CI值为2.11（1.16~3.82）；在 < 90 dB（A）·年累积噪声暴露量下，相比TT基因型，rs 1130409 GG+GT基因型可能是噪声性听力损失发病的危险因素，其调整的OR值及95% CI值为2.76（1.13~6.73）。单体型分析结果显示，CTG（rs2072668-rs1799782-rs2230409）可能是噪声性听力损失发病的危险因素，相比对照组，其调整OR值及95% CI值为1.78（1.21~2.61）。
    结论 rs2072668 CC+CG基因型增加了噪声作业工人患NIHL的风险，提示hOGG1基因单核苷酸多态性可能与NIHL易感性有关。

     

    Abstract:
    Objective The aim of this study was to determine single nucleotide polymorphisms (SNPs)of hOGG1, APEX1 and XRCC1 genes and to identify their association with noise-induced hearing loss(NIHL) in noise-exposed workers.
    Methods A cross-sectional study was performed in the noise-exposed workers in a chemical fiber factory located in Jiangsu Province, including 585 NIHL cases and 619 reference workers according to the measurement of noise level in their workplaces and examination of pure tone audiometry. The SNPs of selected genes were genotyped by TaqMan-PCR technique.
    Results Three candidate genes (hOGG1, XRCC1 and APEX1) were screened. The results of logistic regression analysis showed that under the dominant model, rs2072668 CC+CG genotype may be a risk factor for NIHL compared with rs2072668 GG genotype and its adjusted OR value(95%CI) was 1.40(1.10-1.78)and 2.11(1.16-3.82) while the annual cumulative noise exposure(CNE) was 90-95 dB (A). While the annual CNE was under 90 dB (A), rs 1130409 GG+GT genotype may be a risk factor for NIHL compared with TT genotype and its adjusted OR value (95%CI) was 2.76 (1.13-6.73). Haplotype analysis showed that CTG (rs2072668-rs1799782-rs2230409)may be a risk factor for NIHL and its adjusted OR value (95%CI) was 1.78(1.21-2.61).
    Conclusion Rs2072668 CC+CG genotype may increase the risk of NIHL in noise-exposed workers, which suggested that the SNPs of hOGG1 may be associated with the susceptibility of NIHL.

     

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