李勇, 陈雪, 程淼淼, 李彦. 52年间589例尘肺病例生存分析[J]. 职业卫生与应急救援, 2019, 37(5): 412-415. DOI: 10.16369/j.oher.issn.1007-1326.2019.05.004
引用本文: 李勇, 陈雪, 程淼淼, 李彦. 52年间589例尘肺病例生存分析[J]. 职业卫生与应急救援, 2019, 37(5): 412-415. DOI: 10.16369/j.oher.issn.1007-1326.2019.05.004
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LI Yong, CHEN Xue, CHENG Miaomiao, LI Yan. Survival analysis of 589 pneumoconiosis patients diagnosed in past 52 years[J]. Occupational Health and Emergency Rescue, 2019, 37(5): 412-415. DOI: 10.16369/j.oher.issn.1007-1326.2019.05.004
Citation: LI Yong, CHEN Xue, CHENG Miaomiao, LI Yan. Survival analysis of 589 pneumoconiosis patients diagnosed in past 52 years[J]. Occupational Health and Emergency Rescue, 2019, 37(5): 412-415. DOI: 10.16369/j.oher.issn.1007-1326.2019.05.004
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52年间589例尘肺病例生存分析

Survival analysis of 589 pneumoconiosis patients diagnosed in past 52 years

    摘要
  • 摘要:
    目的 探讨达州市某煤矿尘肺病患者生存状况及其影响因素。
    方法 对1965-2017年诊断报告的589例尘肺病例，采用Kaplan-Meier法与寿命表法进行生存分析，采用Cox回归模型分析影响患者生存时间的因素。
    结果 该煤矿1965-2017年共报告尘肺病例589例，死亡185例，病死率31.41%；中位生存时间31.47年。随着诊断年代的推移，病死率呈降低趋势（P < 0.01），中位生存时间呈上升趋势（P < 0.01）。随着生存时间的增加，尘肺病例的累积生存率逐步降低。相比煤工尘肺组，矽肺组患者生存时间减少的风险增加（OR=1.424，P < 0.05）；相比壹期尘肺组，叁期、贰期尘肺组患者生存时间减少的风险增加（OR=6.210、1.475，P < 0.05）；相比不合并肺结核组，合并肺结核组患者生存时间减少的风险增加（OR=1.570，P < 0.05）；相比不吸烟组，吸烟组患者生存时间减少的风险增加（OR=1.601，P < 0.05）；相比接尘工龄 < 10年组，接尘工龄10~20年、> 20年组患者生存时间减少的风险增加（OR=5.013、7.585，P < 0.05）；相比发病年龄 < 30岁组，发病年龄30~39岁、40~49岁、50~59岁、≥ 60岁组患者生存时间减少的风险增加（OR=3.906~86.572，P < 0.05）。
    结论 尘肺病患者的死亡风险同接尘工龄、尘肺期别、吸烟、肺结核、尘肺病种类及发病年龄均有关。应有效控制危险因素，提高尘肺病患者生活质量，延长其寿命。

     

    Abstract:
    Objective To investigate the survival status and influencing factors of pneumoconiosis patients in a coal mine in Dazhou City.
    Methods All 589 patients with pneumoconiosis diagnosed during 1965 to 2017 were investigated. The Kaplan-Meier method and life table method were used for survival analysis, and Cox regression model was used to analyze the factors affecting the survival time.
    Results Among 589 cases of pneumoconiosis, 185 deaths were reported in this coal mine with a case fatality rate of 31.41% and median survival time was 31.47 years. The fatality rate gradually decreased (P < 0.01) and median survival time became longer (P < 0.01)with the years. The cumulative survival rate for pneumoconiosis cases decreased with increasing survival time. Compared with coal workers' pneumoconiosis, the patients with silicosis had an increased risk of reduced survival time (OR=1.424, P < 0.05). Compared with the cases with stage Ⅰ, patients with stage Ⅲ or Ⅱ had an increased risk of reduced survival time (OR=6.210 or 1.475, P < 0.05). Patients complicated with tuberculosis had an increased risk of reduced survival time compared with those without tuberculosis (OR=1.570, P < 0.05). Compared with the non-smokers, patients with smoking history had an increased risk of reduced survival time (OR=1.601, P < 0.05). Compared with patients with exposure time lower than 10 years, patients with exposure time 10-20 years or longer than 20 years had an increased risk of reduced survival time (OR=5.013 or 7.585, P < 0.05).Compared with patients with the onset age lower 30 years old, patients with the onset age of 30-39, 40-49, 50-59 and older than 59 years old had increased risk of reduced survival time (ORs varied from 3.906 to 86.572, P < 0.05).
    Conclusion The death risk of pneumoconiosis patients was related to the dust types and exposure time, the pneumoconiosis stage, smoking behavior, the complication of tuberculosis, and age of onset. The risk factors should be effectively controlled to improve the life quality and prolong the life span of pneumoconiosis patients.

     

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