谢良斌, 曹艳梅, 闵春燕. 尘肺病患者外周血维生素D与淋巴细胞亚群、炎症因子的相关性研究[J]. 职业卫生与应急救援, 2021, 39(1): 21-26. DOI: 10.16369/j.oher.issn.1007-1326.2021.01.006
引用本文: 谢良斌, 曹艳梅, 闵春燕. 尘肺病患者外周血维生素D与淋巴细胞亚群、炎症因子的相关性研究[J]. 职业卫生与应急救援, 2021, 39(1): 21-26. DOI: 10.16369/j.oher.issn.1007-1326.2021.01.006
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XIE Liangbin, CAO Yanmei, MIN Chunyan. Correlations between vitamin D and inflammatory factors and lymphocyte subpopulation in patients with pneumoconiosis[J]. Occupational Health and Emergency Rescue, 2021, 39(1): 21-26. DOI: 10.16369/j.oher.issn.1007-1326.2021.01.006
Citation: XIE Liangbin, CAO Yanmei, MIN Chunyan. Correlations between vitamin D and inflammatory factors and lymphocyte subpopulation in patients with pneumoconiosis[J]. Occupational Health and Emergency Rescue, 2021, 39(1): 21-26. DOI: 10.16369/j.oher.issn.1007-1326.2021.01.006
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尘肺病患者外周血维生素D与淋巴细胞亚群、炎症因子的相关性研究

Correlations between vitamin D and inflammatory factors and lymphocyte subpopulation in patients with pneumoconiosis

    摘要
  • 摘要:
      目的  了解尘肺病患者的维生素D水平，并分析维生素D与炎症因子、淋巴细胞亚群各指标之间的相关性。
      方法  选取60名老年男性健康体检人员为对照组，182名尘肺病患者为研究组，比较两组的维生素D水平；同时分析研究组维生素D水平、尘肺病期别与炎症因子、淋巴细胞亚群的相关性。
      结果  182名尘肺病患者维生素D缺乏人员的占比高于对照组（P < 0.05）。研究组平均25（OH）D水平为（21.55 ±9.51）ng/mL，显著低于对照组的（27.16 ±8.12）ng/mL（P < 0.01）。182名尘肺病患者的炎症因子，包括白介素2受体（IL-2R）、白介素-6（IL-6）、白介素-8（IL-8）、降钙素原（PCT）、C反应蛋白（CRP）随着尘肺病期别的升高而升高（P < 0.05）；IL-6在维生素D充足组最低（P < 0.05），IL-8、PCT及CRP随着25（OH）D水平的升高逐渐降低（P < 0.05）；壹期尘肺病患者CD4/CD8值高于贰、叁期患者（P < 0.05），CD4 +T细胞、L/CD45随着尘肺分期的升高而降低（P < 0.05）；随着25（OH）D水平的升高，CD4 +T细胞占比、L/CD45逐渐升高，而CD8 +T细胞逐渐下降；25（OH）D与CRP水平呈弱的负相关（r=-0.191，P < 0.05），25（OH）D与IL-10、CD4/CD8值、L/CD45呈弱的正相关（r=0.299、0.176、0.257，P < 0.05）。
      结论  尘肺病患者维生素D缺乏或不足率较高，尘肺病患者体内的维生素D可能通过调节炎症因子及细胞因子参与炎症反应及免疫功能。

     

    Abstract:
      Objective  To understand the vitamin D concentration of pneumoconiosis patients and its correlation with inflammatory factors and lymphocyte subpopulation.
      Methods  Totally 182 pneumoconiosis patients and 60 elderly male healthy persons were studied. The vitamin D levels of the two groups were compared. The correlation of vitamin D level with pneumoconiosis stage, inflammatory factors, and lymphocyte subsets in the study group was analyzed.
      Results  The proportion of vitamin D deficiency in 182 pneumoconiosis patients was higher than that in the control group (P < 0.05). The average level of 25(OH)D in study group was(21.55 ±9.51)ng/mL, significantly lower than that in the control group (27.16 ±8.12)ng/mL(P < 0.01). The level of inflammatory factors, including IL-2R, IL-6, IL-8, PCT and CRP increased gradually with the increment of pneumoconiosis stage (P < 0.05). IL-6 was the lowest in vitamin D sufficient group(P < 0.05), and IL-8, PCT and CRP decreased with the increase of 25(OH)D leve(l P < 0.05). The ratio of CD4/CD8 in patients with stage I pneumoconiosis was higher than that in patients with stage 2 and stage 3 pneumoconiosis(P < 0.05);CD4 +T cells and L/CD45 decreased with the increase of pneumoconiosis stage (P < 0.05). With the increase of 25(OH)D level, the ratio of CD4 +T cells and L/CD45 increased gradually, while CD8 +T cells decreased gradually. There was a weak negative correlation between 25(OH)D and CRP level(r=-0.191, P < 0.05), and a weak positive correlation of 25 (OH)D with IL-10, CD4/CD8 ratio, and L/CD45 (r=0.299, 0.176, 0.257, P < 0.05, respectively).
      Conclusions  Vitamin D deficiency or insufficient was common in pneumoconiosis patients. Vitamin D may be involved in inflammation and immune functions by regulating inflammatory factors and lymphocyte subpopulation.

     

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