郭翔, 谢玉璇, 李添娣, 惠长野, 沙焱. 正交设计评价吸附剂清除百草枯和敌草快的体外试管实验[J]. 职业卫生与应急救援, 2021, 39(5): 504-508. DOI: 10.16369/j.oher.issn.1007-1326.2021.05.005
引用本文: 郭翔, 谢玉璇, 李添娣, 惠长野, 沙焱. 正交设计评价吸附剂清除百草枯和敌草快的体外试管实验[J]. 职业卫生与应急救援, 2021, 39(5): 504-508. DOI: 10.16369/j.oher.issn.1007-1326.2021.05.005
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GUO Xiang, Xie Yuxuan, LI Tiandi, HUI Changye, SHA Yan. Evaluation of effect of adsorbents for paraquat and diquat by in vitro tube test with orthogonal design[J]. Occupational Health and Emergency Rescue, 2021, 39(5): 504-508. DOI: 10.16369/j.oher.issn.1007-1326.2021.05.005
Citation: GUO Xiang, Xie Yuxuan, LI Tiandi, HUI Changye, SHA Yan. Evaluation of effect of adsorbents for paraquat and diquat by in vitro tube test with orthogonal design[J]. Occupational Health and Emergency Rescue, 2021, 39(5): 504-508. DOI: 10.16369/j.oher.issn.1007-1326.2021.05.005
shu

正交设计评价吸附剂清除百草枯和敌草快的体外试管实验

Evaluation of effect of adsorbents for paraquat and diquat by in vitro tube test with orthogonal design

    摘要
  • 摘要:
      目的  通过体外试管实验方法，评价消化道吸附剂清除百草枯和敌草快的效果。
      方法  通过正交设计以体外试管实验探索毒物质量浓度、吸附剂种类、反应时间和酸碱度4个因素对百草枯和敌草快清除能力的影响。
      结果  吸附剂种类、反应时间和酸碱度对百草枯和敌草快清除率的影响差异有统计学意义（P < 0.05）。对百草枯清除率影响程度大小的顺序为吸附剂种类>反应时间>酸碱度；对敌草快清除率影响程度大小的顺序为吸附剂种类>酸碱度>反应时间。上述因素清除百草枯和敌草快的最佳组合为pH=12的环境下，采用蒙脱石散为吸附剂、反应时间120 min。
      结论  体外试管实验条件下，常用吸附剂蒙脱石散、活性炭粉和捣碎的药用炭片均可有效清除百草枯和敌草快。吸附剂种类、反应时间和酸碱度对百草枯和敌草快的清除率均有影响。

     

    Abstract:
      Objective  To study the clearance of gastrointestinal adsorbents against paraquat and diquat by in vitro tube test.
      Methods  The effects of poison mass concentration, adsorbent type, reaction time and pH value on the rapid scavenging ability of paraquat and diquat were studied by orthogonal design and in vitro tube test.
      Results  The results showed that adsorbents, reaction time and pH value significantly influenced the absorption rate of paraquat and diquat(P < 0.05). The order of factors affecting absorption rate of paraquat was adsorbents > reaction time > pH value; the order of factors affecting the absorption rate of diquat was adsorbents > pH value > reaction time. Orthogonal experiments indicated that the optimal prescription were pH=12, montmorillonite as absorbent and reaction time=120 min.
      Conclusions  In vitro tube test show that gastrointestinal adsorbents(Montmorillonite powder, activated carbon powder and crushed medicinal carbon tablets) could clear paraquat and diquat. Adsorbents, reaction time and pH value could influence the absorption rate of paraquat and diquat.

     

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