Objective  To investigate the influence of occupational radiation exposure on biological effect indexes of interventional radiologists.

  Methods  During 2017 to 2020, 873 medical staff engaged in interventional therapy, 548 compartment operators and 433 newly staff (pre-job physical examination, as reference group) were analyzed for chromosome aberration of peripheral blood lymphocytes, micronucleus rate, blood cell count and ophthalmic examination, and personal radiation dose was monitored.

  Results  The average annual effective dose of medical staff engaged in interventional therapy was higher than that of compartment operators(P < 0.01). The detection rates of no centromeric fragment, bicentromere and total chromosome aberration of medical staff engaged in interventional therapy were significantly higher than those of compartment operators and of the members in reference group(P < 0.05/3). The abnormal lens rate of medical staff engaged in interventional therapy was significantly higher than that of the reference group(P < 0.05/3). There was no significant difference of most blood cell indexes among these three groups (P > 0.05). Among medical staff engaged in interventional therapy, the detection rate of micronucleus and the abnormal rate of ocular lens increased with the working year(P < 0.01), while there was no such trend of other indexes observed(P > 0.05). There was no similar trends observed among compartment operators(P > 0.05).

  Conclusions  Higher occupational radiation exposure may have a certain impact on the biological effect index of medical staff engaged in interventional therapy, so it is necessary to strengthen the radiation protection and reduce the ionizing radiation damage effect.