毛一扬, 周信, 李小琴, 许培, 窦建瑞, 鄂蒙. 工作场所石棉暴露与肾癌之病例-对照研究的meta分析[J]. 职业卫生与应急救援, 2022, 40(2): 145-149. DOI: 10.16369/j.oher.issn.1007-1326.2022.02.004
引用本文: 毛一扬, 周信, 李小琴, 许培, 窦建瑞, 鄂蒙. 工作场所石棉暴露与肾癌之病例-对照研究的meta分析[J]. 职业卫生与应急救援, 2022, 40(2): 145-149. DOI: 10.16369/j.oher.issn.1007-1326.2022.02.004
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MAO Yiyan, ZHOU Xin, LI Xiaoqin, XU Pei, DOU Jianrui, E Meng. A meta-analysis of a case-control study of asbestos exposure and renal cell carcinoma in workplaces[J]. Occupational Health and Emergency Rescue, 2022, 40(2): 145-149. DOI: 10.16369/j.oher.issn.1007-1326.2022.02.004
Citation: MAO Yiyan, ZHOU Xin, LI Xiaoqin, XU Pei, DOU Jianrui, E Meng. A meta-analysis of a case-control study of asbestos exposure and renal cell carcinoma in workplaces[J]. Occupational Health and Emergency Rescue, 2022, 40(2): 145-149. DOI: 10.16369/j.oher.issn.1007-1326.2022.02.004
shu

工作场所石棉暴露与肾癌之病例-对照研究的meta分析

A meta-analysis of a case-control study of asbestos exposure and renal cell carcinoma in workplaces

    摘要
  • 摘要:
      目的  探究职业接触石棉与患肾癌风险的关系。
      方法  检索有关职业接触石棉与患肾癌的电子文献数据库（中国知网、维普、万方、PubMed、EBSCO、Elsevier Science direct、Medical、Cochrane Library），根据Newcastle-Ottawa scale（NOS）量表评价纳入文献的质量，对评价低于6分的文献不予纳入。用STATA12.0软件对文献的OR值及其95%置信区间进行合并。通过I2及P值对合并后的数据进行异质性检验。使用敏感性分析判定结果的稳定性，并做亚组分析。
      结果  共检索到文献248篇，最终纳入8篇文章、10个病例-对照研究，病例组3 725例，对照组6 970例。10项研究之间存在较低的异质性（I2 < 0.1%，P = 0.585）。合并的效应值表明工作场所接触石棉会增加患肾癌的风险（OR = 1.30，95% CI：1.17 ~ 1.45，P < 0.01）。敏感性分析和亚组分析均证实了本次结果较稳定，并且未见明显的发表偏倚。
      结论  工作场所接触石棉会增加患肾癌的风险。

     

    Abstract:
      Objective  To explore the relationship between occupational exposure to asbestos and the risk of renal cancer.
      Methods  Based on the electronic databases(Wanfang database, CNKI database, VIP database, PubMed, EMBASE and Cochrane Library), the literatures related to occupational asbestos exposure and renal cancer were searched. The quality of the included literature was evaluated according to the Newcastle Ottawa scale(NOS), and the literature with an evaluation score of less than 6 was not included. The OR value and 95% confidence interval of the literatures were combined using Stata 12.0 software. The combined data were tested for heterogeneity by I2 and P values. Sensitivity analysis was used to determine the stability of the results, and subgroup analysis was performed.
      Results  A total of 248 literatures were retrieved, and finally 8 articles and 10 case-control studies were included. There were 3 725 cases in the case group and 6 970 cases in the control group. There was low heterogeneity among 10 studies (I2 < 0.1%, P = 0.585). The combined effect values showed that exposure to asbestos in the workplaces increased the risk of kidney cancer(OR = 1.30, 95% CI: 1.17-1.45, P < 0.01). Sensitivity analysis and subgroup analysis confirmed that the results were stable, and there was no significant publication bias.
      Conclusion  Exposure to asbestos in the workplaces could increase the risk of renal cancer.

     

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