李晓亮, 陈先锋, 吴一帆, 张璟. 职业接触拟除虫菊酯工人精子浓度的调查[J]. 职业卫生与应急救援, 2022, 40(6): 650-654. DOI: 10.16369/j.oher.issn.1007-1326.2022.06.004
引用本文: 李晓亮, 陈先锋, 吴一帆, 张璟. 职业接触拟除虫菊酯工人精子浓度的调查[J]. 职业卫生与应急救援, 2022, 40(6): 650-654. DOI: 10.16369/j.oher.issn.1007-1326.2022.06.004
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LI Xiaoliang, CHEN Xianfeng, WU Yifan, ZHANG Jing. Investigation on sperm concentration of workers occupationally exposed to pyrethroids[J]. Occupational Health and Emergency Rescue, 2022, 40(6): 650-654. DOI: 10.16369/j.oher.issn.1007-1326.2022.06.004
Citation: LI Xiaoliang, CHEN Xianfeng, WU Yifan, ZHANG Jing. Investigation on sperm concentration of workers occupationally exposed to pyrethroids[J]. Occupational Health and Emergency Rescue, 2022, 40(6): 650-654. DOI: 10.16369/j.oher.issn.1007-1326.2022.06.004
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职业接触拟除虫菊酯工人精子浓度的调查

Investigation on sperm concentration of workers occupationally exposed to pyrethroids

    摘要
  • 摘要:
      目的  调查拟除虫菊酯暴露与工人体内氧化应激状态和精子浓度的关联性，为制定拟除虫菊酯职业暴露引起男性职业性生殖毒性损害的诊断标准提供依据。
      方法  2020年9-10月，选取武汉市某拟除虫菊酯类农药工厂一线岗位234名成年男性工人为暴露组，117名成年男性行政后勤人员为对照组，收集调查对象的一般人口学信息并采集尿液5mL，检测尿中3-苯氧基苯甲酸(3-PBA)、8-羟氧基苯甲酸(8-OHdG)浓度；采集调查对象禁欲3d后的精液，测量精子浓度。同时检测该工厂生产工人主要接触的化学有害因素浓度。
      结果  生产工人主要接触的化学有害因素为: 溴氰菊酯、氯氰菊酯、高效氯氰菊酯和顺式氯氰菊酯。暴露组人员的3-PBA浓度、8-OHdG浓度均高于对照组，精子浓度低于对照组，差异均有统计学意义(P < 0.01)。经Person相关性检验，351名研究对象3-PBA浓度与8-OHdG浓度呈正相关(r=0.511，P < 0.01)，与精子浓度呈负相关(r=-0.546，P < 0.01)；8-OHdG浓度(经自然对数转换)与精子浓度呈负相关(r=-0.113，P < 0.05)。线性回归模型分析结果显示: (1)尿中3-PBA浓度(经自然对数转换)每增加1μg/g，8-OHdG浓度增加7.362μg/g，精子浓度减少0.136×108个/mL；(2)BMI每增加1kg/m2，8-OHdG浓度增加0.396μg/g，精子浓度减少0.014×108个/mL。未观察到年龄、吸烟、饮酒与8-OHdG浓度、精子浓度之间的剂量-效应关系。
      结论  拟除虫菊酯暴露可能会升高男性职业接触人群氧化应激水平，降低精子浓度，应加强工人的职业防护。

     

    Abstract:
      Objective  To investigate the correlation between occupational pyrethroid exposure and oxidative stress status and sperm in workers, so as to provide a scientific basis for formulating diagnostic criteria of male reproductive damage caused by occupational pyrethroid exposure.
      Methods  From September to October 2020, 234 adult male workers and 117 adult male administrative and logistics personnel (as the control group) in a pyrethroid pesticide factory in Wuhan were studied. The sperm was measured after 3 days of abstinence. Concentration of exposed chemicals at workplaces in the factory was measured.
      Results  The occupationally exposed chemicals were deltamethrin, cypermethrin, beta cypermethrin and cis cypermethrin. The urinary of 3 -PBA and 8 -OHdG of the exposed workers was higher than that in the control group, while the of sperm was lower than that in the control group (P < 0.01). Pearson correlation test showed that the of 3-PBA in 351 subjects was positively correlated with the of 8-OHdG(r=0.511, P < 0.01), and negatively correlated with the of sperm(r=- 0.546, P < 0.01); the of 8-OHdG was negatively correlated with sperm (r=-0.113, P < 0.05). The results of linear regression model analysis showed that with every 1 μg/g increasing in urine 3 -PBA (converted by natural logarithm), 8-OHdG increased by 7.362 μg/g and sperm decreased by 0.136 × 108 /mL; when BMI increased by 1 kg/m2, 8 -OHdG increased by 0.430 μg/g and sperm decreased by 0.014 × 108/mL. No dose effect relationship was observed among age, smoking, drinking and 8 -OHdG or sperm.
      Conclusions  Occupational pyrethroid exposure may induced the increment of oxidative stress level and reduction of sperm. The occupational work on protection of workers should be strengthened.

     

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