张志平, 王晓宇, 鄂蒙, 毛一扬. 职业性接触电焊烟尘与慢性阻塞性肺疾病风险关系的meta分析[J]. 职业卫生与应急救援, 2023, 41(3): 342-346. DOI: 10.16369/j.oher.issn.1007-1326.2023.03.018
引用本文: 张志平, 王晓宇, 鄂蒙, 毛一扬. 职业性接触电焊烟尘与慢性阻塞性肺疾病风险关系的meta分析[J]. 职业卫生与应急救援, 2023, 41(3): 342-346. DOI: 10.16369/j.oher.issn.1007-1326.2023.03.018
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ZHANG Zhiping, WANG Xiaoyu, E Meng, MAO Yiyang. Meta-analysis of relationship between occupational exposure to welding fumes and risk of chronic obstructive pulmonary disease[J]. Occupational Health and Emergency Rescue, 2023, 41(3): 342-346. DOI: 10.16369/j.oher.issn.1007-1326.2023.03.018
Citation: ZHANG Zhiping, WANG Xiaoyu, E Meng, MAO Yiyang. Meta-analysis of relationship between occupational exposure to welding fumes and risk of chronic obstructive pulmonary disease[J]. Occupational Health and Emergency Rescue, 2023, 41(3): 342-346. DOI: 10.16369/j.oher.issn.1007-1326.2023.03.018
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职业性接触电焊烟尘与慢性阻塞性肺疾病风险关系的meta分析

Meta-analysis of relationship between occupational exposure to welding fumes and risk of chronic obstructive pulmonary disease

    摘要
  • 摘要:
      目的  探讨职业接触电焊烟尘与慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）的关系。
      方法  检索从建库到2022年有关电焊烟尘和COPD的文献，数据库包括PubMed、Springer、中国知网和万方等。采用美国医疗保健研究和质量局（AHRQ）量表对符合标准的文章进行质量评估。根据I2和P值对文章进行异质性判断，并选用相应的效应模型。通过敏感性分析检验研究结果的稳定性；通过Begg’s和Egger’s检验评估发表偏倚。
      结果  共检索到相关文献108篇，最终有2项队列研究和6项横断面研究共11项研究纳入本次meta分析，未接触电焊烟尘的有3 425例COPD患者，接触电焊烟尘的有193例COPD患者。文献质量评分均在5分以上。各研究间异质性较低（I2 = 11.8%），采用固定效应模型对合并优势比（OR）进行分析。合并OR值表明接触电焊烟尘会增加COPD的发病风险（OR = 1.39，95%CI = 1.15 ~ 1.69），在控制了吸烟因素后依旧显示接触电焊烟尘会增加COPD的发病风险（OR=1.34，95%CI：1.10 ~ 1.63）。敏感性分析证实本次研究结果稳定。
      结论  劳动过程中接触电焊烟尘可增加职业人群患COPD的风险，应重视电焊烟尘工作人员的健康监护，及早控制可能的病情，在脱离岗位后要保持定期随访。

     

    Abstract:
      Objective  To explore the relationship between occupational exposure to welding fumes and chronic obstructive pulmonary disease (COPD).
      Methods  Literature on welding fumes and COPD from databases until 2022 was retrieved, including PubMed, Springer, China Knowledge Network, Wanfang, etc. The quality of articles that met the criteria was evaluated using the Health Research and Quality (AHRQ) scale. The heterogeneity of articles was judged according to I2 and P values, and the corresponding effect model was selected. The stability of research results was tested by sensitivity analysis; Begg's and Egger's tests were used to evaluate publication bias.
      Results  A total of 108 relevant articles were retrieved, and 11 studies, including 2 cohort studies and 6 cross-sectional studies, were finally included in this meta-analysis. There were 3 425 COPD patients who had not been exposed to welding fumes and 193 COPD patients who had been exposed to welding fumes. The quality scores of the articles were all above 5 points. The heterogeneity among studies was low (I2 = 11.8%), and a fixed-effect model was used to analyze the combined odds ratio (OR). The combined OR value showed that exposure to welding fumes would increase the risk of COPD (OR = 1.39, 95%CI: 1.15-1.69), which still showed that exposure to welding fumes would increase the risk of COPD after controlling for the smoking factor (OR = 1.34, 95% CI: 1.10-1.63). Sensitivity analysis confirmed that the results of this study were stable.
      Conclusions  Occupational exposure to welding fumes can increase the risk of COPD in occupational populations. Attention should be paid to the health monitoring of workers exposed to welding fumes, early control of possible conditions, and regular followup after leaving their posts.

     

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