刘丽容, 杨梅. 采用枸橼酸局部抗凝血液净化治疗含鹅膏毒肽蘑菇中毒伴血小板减少1例[J]. 职业卫生与应急救援, 2023, 41(6): 773-775. DOI: 10.16369/j.oher.issn.1007-1326.2023.06.023
引用本文: 刘丽容, 杨梅. 采用枸橼酸局部抗凝血液净化治疗含鹅膏毒肽蘑菇中毒伴血小板减少1例[J]. 职业卫生与应急救援, 2023, 41(6): 773-775. DOI: 10.16369/j.oher.issn.1007-1326.2023.06.023
LIU Lirong, YANG Mei. Application of local anticoagulant decontamination with citrate in the treatment of a patient with amanitin mushroom poisoning with thrombocytopenia[J]. Occupational Health and Emergency Rescue, 2023, 41(6): 773-775. DOI: 10.16369/j.oher.issn.1007-1326.2023.06.023
Citation: LIU Lirong, YANG Mei. Application of local anticoagulant decontamination with citrate in the treatment of a patient with amanitin mushroom poisoning with thrombocytopenia[J]. Occupational Health and Emergency Rescue, 2023, 41(6): 773-775. DOI: 10.16369/j.oher.issn.1007-1326.2023.06.023

采用枸橼酸局部抗凝血液净化治疗含鹅膏毒肽蘑菇中毒伴血小板减少1例

Application of local anticoagulant decontamination with citrate in the treatment of a patient with amanitin mushroom poisoning with thrombocytopenia

  • 摘要: 鹅膏毒肽广泛存在于自然界的多种蘑菇中,进食后可导致肝、肾坏死,目前治疗上无特效解毒剂。通过回顾性分析1例误食含鹅膏毒肽的条盖盔孢菌致肝衰竭患者的救治经过,说明血液净化是减轻鹅膏毒肽对人体健康损害的重要治疗方式,而抗凝方式是否合适直接关系到血液净化能否顺利实施。该例中毒患者伴严重血小板减少、持续无尿、全身水肿,给予双重血浆分子吸附系统(DPMAS)+血浆置换(PE)+连续肾脏替代疗法(CRRT)的血液净化治疗、采用枸橼酸局部抗凝后,患者于入院第10天转入普通病房继续治疗,并康复出院。建议在对肝衰竭患者进行血液净化时,可适当放宽枸橼酸的使用指征。

     

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