Abstract: Objective The characterization of chronic occupational benzene poisoning cases diagnosed in Baoan District over the past decade were analyzed, to provide the orientation for specific prevention and control of benzene hazards. Methods The records of the chronic benzene poisoning cases were inquired and the related information on occupational health work of the enterprises in which the cases worked were extracted from governmental management files. Results There were 74(male 37 and female 37)cases diagnosed with chronic benzene poisoning in Baoan District in recent ten years. They came from 59 enterprises and 53 cases were diagnosed in recent 3 years. It showed there was a increasing trend of incidence with time going(χ²=36.277, P<0.01). Most cases worked in the printing,electron,plastic,and hardware industries. Among these 59 enterprises,only one enterprise carried out the occupational health evaluation after they put into production and 17 enterprises were equipped with protective equipment and provided the workers with personal protective equipment. Conclusion The chronic benzene poisoning cases in Baoan District was increasing in recent years.The cases can be found almost in all enterprises using organic solvents. More attention should be given to such enterprises and supervision to these enterprises should be strengthened.