Abstract: Objective To explore the role of comprehensive nursing intervention in patients with trichloroethylene induced medicamentosa-like dermatitis. Methods The comprehensive nursing interventions were given in 84 hospitalized cases with trichloroethylene induced medicamentosa-like dermatitis from 2006 to 2013,the effectiveness in promoting the rehabilitation,reducing the infection incidence and preventing complications were evaluated. Results Among 84 cases,72 cases were cured(85.7%),9 cases were improved(10.7%)and 3 cases died(3.6%). There were no secondary infection occurred in patients with severe liver damage,and no complication occurred in all patients with catheters. Conclusion The comprehensive nursing intervention can improve the prognosis of trichloroethylene induced medicamentosa-like dermatitis patients.