Abstract: The delayed encephalopathy could occur among the moderate or severe cases with acute carbon monoxide poisoning after latent phase,which is characterized mainly with neuropsychiatric symptoms. This article summarized the updated research on risk factors and pathogenesis of this delayed encephalopathy induced by acute carbon monoxide poisoning,and presumed both the risk factors and the pathogenesis of the disease were not well clarified yet,more research on this subject is needed in the future.