Abstract: Objective To observe the serum adiponectin level and its relation with occupational stress. Methods A cross-sectional study was conducted and a total of 220 staffs with working time more than 3 years in a company were surveyed. The questionnaires of Occupational Stress Inventory Revised Edition(OSI-R)were used in this study, while the body mass index(BMI)and serum adiponectin were tested. Results It showed that there were statistical differences between men and women in the levels of adiponectin and occupational stress. Serum adiponectin level was negatively correlated with body mass index,age and occupational stress. The OR was 2.458;1.432 and 1.075, respectively. Conclusion Occupational stress,BMI and age were major risk factors for lower serum adiponectin.