荧光增白剂致中华仓鼠肺细胞染色体畸变研究

蒋伟; 陈相; 缪文彬; 朱洪坤

荧光增白剂致中华仓鼠肺细胞染色体畸变研究

上海出入境检验检疫局, 上海 200135

基金项目:

国家质检总局科技计划项目(2011IK042)。

详细信息

作者简介:
蒋伟(1969-),男,大学本科,研究员,主要从事化学品分类与鉴定。

中图分类号: R114
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出版历程
- 收稿日期: 2013-01-16
- 修回日期: 2013-02-27

Chromosome aberration of Chinese hamster lung cells induced by fluorescent brightener

Shanghai Entry-exit Inspection and Quarantine Bureau, Shanghai 200135, China

摘要

摘要: [目的]荧光增白剂是国家安全生产监督管理总局2011年颁布的《职业病危害因素分类表》中定性的化学毒物,本研究探讨荧光增白剂染毒对体外哺乳动物细胞的染色体的影响,为荧光增白剂遗传损伤机制的研究提供科学依据。[方法]使用不同浓度的荧光增白剂28处理中国仓鼠肺细胞,通过体外哺乳动物染色体畸变实验检测细胞的染色体畸变程度。[结果]在有代谢活化系统条件下,各剂量染毒组结构畸变细胞率与阴性对照组相比,差异无统计学意义。[结论]本研究未显示荧光增白剂28造成体外哺乳动物细胞染色体损伤。
- 荧光增白剂 /
- 体外哺乳动物细胞染色体畸变实验 /
- 遗传物质损伤
+ English
Abstract: [Objective] Fluorescent brightener is one of chemicals listed in "Classification Chart of Occupational Hazardous" announced by SAWS. In order to understand the mechanism of genetic damage, the chromosome damage induced by fluorescent brightener on CHL (Chinese hamster lung) cells was studied. [Methods] CHL cells were treated with different concentrations of fluorescent brightener 28 in vitro and chromosome aberration of treated CHL cells was detected. [Results] Under the testing conditions with an exogenous source of metabolic activation system(S9), there was no significant increasing percentage of cells with structural aberrations in treated groups, compared with negative control. [Conclusion] Fluorescent brightener 28 may not induce chromosome damage in cultured mammalian cells.
- Fluorescent brightener /
- Mammalian cell chromosome aberration test in vitro /
- Genetic damage

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参考文献(9)

[1]	夏宝凤,汪森榕. 荧光增白剂所致成衣工职业性皮肤疾患65例报告[J].中国工业医学杂志, 1994;7(3):182-183.
[2]	Köhler A. Organic pollutant removal versus toxicity reduction in industrial wastewater treatment:the example of wastewater from fluorescent whitening agent production[J]. Environ Sci Technol, 2006,40(10):3395-3401.
[3]	仲伟鉴,董妙珠,肖萍等. 卫生纸中荧光增白剂的光毒、光敏和致突变性研究[J]. 上海预防医学杂志,1999(11):521-523.
[4]	沈永嘉,许煦. 荧光增白剂的毒性[J]. 化工科技市场,2002(8):5-8.
[5]	贾光,刘世杰. 应用台盼蓝拒染法与MTT法判断Cr细胞毒性的比较[J].中国职业医学,2000,27(3):49.
[6]	王立鑫, 赵彬, 刘聪,等. 室内邻苯二甲酸酯(PAEs)暴露量分析[J].建筑科学,2010,26(6):73-80.
[7]	OECD. In Vitro Mammalian Chromosome Aberration Test[R]. Pairs:Organization For Economic Cooperation And Development, 1997:1-10.
[8]	唐萌,董菊,李倩,等. 八氯二丙醚对中国仓鼠肺细胞染色体畸变作用[J].中国公共卫生,2004,20(12):1422-1424.
[9]	OECD. In Vitro Mammalian Cell Micronucleus Test[R]. Pairs:Organization For Economic Cooperation And Development, 2010:1-13.

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文章访问数: 407
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荧光增白剂致中华仓鼠肺细胞染色体畸变研究

作者简介: 蒋伟(1969-),男,大学本科,研究员,主要从事化学品分类与鉴定。

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出版历程

Chromosome aberration of Chinese hamster lung cells induced by fluorescent brightener

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出版历程

目录

作者简介:
蒋伟(1969-),男,大学本科,研究员,主要从事化学品分类与鉴定。