Abstract: Objective To understand the reality of occurrence of occupational diseases in Shenzhen recently,and to provide the evidence for the priority decision in prevention and control of occupational diseases. Methods The reporting data of newly diagnosed cases of occupational diseases from 2006 to 2010 was analyzed, including clinical characteristics,distribution of districts and industries where the cases were reported. Results There were 504 newly diagnosed cases in Shenzhen from 2006 to 2010,and there was an increasing trend since 2007. The major classifications of occupational diseases included chronic occupational poisoning(30.36%,mostly due to n-hexane and benzene), pneumoconiosis(25.40%), trichlorethylene-induced dermatitis(8.93%), and occupational noise deafness(7.14%). The newly occupational diseases were mainly from the enterprises located in Bao'an Dstrict and Long Gang District. Most cases were diagnosed in the small and medium-sized private enterprises, light industry and electronics industry. Conclusion Chronic occupational poisoning,Trichlorethylene Dermatitis,Pneumoconiosis,and occupational noise deafness were common occupational diseases in Shenzhen,more attention should be paid to the prevention and control of such occupational hazards,especially in the small and medium-sized private enterprises.