Abstract: Objective To assess the health risk caused by the occupational hazards during domestic refuse incineration. Methods Based on the potential impact severity and exposure probability of occupational hazards, the health risk in a certain domestic refuse incinerating factory of Shanghai was assessed using the available model. Results Through systematic analysis, the health risk level was evaluated and the priorities for the occupational health work in this company was determined in the main operation units. Conclusion Effective risk assessment and analysis could provide us with the directive information for risk control of occupational hazards in sectors of domestic refuse incineration.