Updated information on neurotoxicity study of 1-bromopropane
-
+ English摘要: 1-溴丙烷作为臭氧层破坏物氟氯烃类替代品之一而被广泛推广使用,然而1-溴丙烷中毒事件的报道,促使对其进行职业人群流行病学的研究,结果表明1-溴丙烷对人具有潜在的神经毒性,会引起人体外周神经传导速度降低、下肢振动觉下降、共济失调等症状体征。为尝试解释1-溴丙烷的神经毒性作用机制,同时也进行了动物实验研究。国内外学者对1-溴丙烷神经毒性方面的研究资料已进行过整理,在此基础上,就近几年1-溴丙烷神经毒性的研究进展作一简要综述。
-
-
[1] The National Toxicology Program. Draft report on carcinogens monograph for 1-bromopropane[R]. Washington,D C:U S Department of Health and Human Services,2013.
[2] 宋福永,谢克勤. 1-溴丙烷毒性研究进展[J]. 中华劳动卫生职业病杂志,2010,28(7):548-551. [3] 李卫华,胡晓晴,田芳,等. 1-溴丙烷职业接触限值研究进展[J]. 环境与职业医学,2010,27(7):191-196. [4] The National Toxicology Program. Toxicology and carcinogenesis studies of 1-Bromopropane[R]. Washington,D C:U S Department of Health and Human Services,2011.
[5] Ichihara G. Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane[J]. Int Arch Occup Environ Health, 2005,78(2):79-96.
[6] 王强毅,李卫华,李洁斐,等. 1-溴丙烷的神经毒性及作用机制研究进展[J]. 环境与职业医学,2007,24(6):3. [7] Ichihara G,Kitoh J,Li W,et al. Neurotoxicity of 1-bromopropane:evidence from animal experiments and human studies[J]. J Adv Res,2012,3(2):91-98.
[8] Sclar G. Encephalomyeloradiculoneuropathy following exposure to an industrial solvent[J]. Clin Neurol Neurosurg,1999,101(3):199-202.
[9] Ichihara G,Miller J K,Ziolkowska A,et al. Neurological disorders in three workers exposed to 1-bromopropane 2002[J]. J Occup Health,2002,44(2):1.
[10] Majersik J J,Caravati E M,Steffens J D. Severe neurotoxicity associated with exposure to the solvent 1-bromopropane (n-propyl bromide)[J]. Clin Toxicol,2007,45(3):270-276.
[11] Raymond L W,Ford M D. Severe illness in furniture makers using a new glue:1-bromopropane toxicity confounded by arsenic[J]. J Occup Environ Med,2007,49(9):1009-1019.
[12] Centers for Disease Control and Prevention(CDC). Neurologic illness associated with occupational exposure to the solvent 1-bromopropane-New Jersey and Pennsylvania,2007-2008[J]. MMWR,2008,57(48):1300-1302.
[13] 彭四盟,李卫华,范奇元,等. 1-溴丙烷工厂工人健康状况调查及接触生物标记物的研究[J]. 职业与健康,2003,19(1):3. [14] 徐甫,丁道正,周志俊,等. 某1-溴丙烷生产企业职业卫生调查[J]. 环境与职业医学,2013,30(7):532-535. [15] Ichihara G,Li W H,Ding X C,et al. A survey on exposure level,health status,and biomarkers in workers exposed to 1-bromopropane[J]. Am J Ind Med,2004,45(1):63-75.
[16] 钟志霞,陈晶晶,毕业,等. 1-溴丙烷暴露对大鼠认知功能的影响[J]. 中华劳动卫生职业病杂志,2011,29(8):593-596. [17] 王清华,钟志霞,赵秀兰,等. 1-溴丙烷经口染毒致大鼠周围神经病模型的建立[J]. 中华劳动卫生职业病杂志,2012,30(10):751-755. [18] 邬春华,徐甫, 常秀丽, 等. 工作场所空气中1-溴丙烷的气相色谱测定法[J]. 中华劳动卫生职业病杂志, 2013,31(6):467-469. [19] 徐甫,常秀丽,周志俊. 1-溴丙烷暴露生物标志研究进展[J]. 职业卫生与应急救援,2012,30(4):194-201. [20] Ichihara G,Li W, Shibata E,et al. Neurologic abnormalities in workers of a 1-bromopropane factory[J]. Environ Health Perspect,2004,112(13):1319-1325.
[21] Ichihara G,Li W,Shibata E. Exposure to 1-bromopropane adversely affects vibration sense and nerve conduction velocity of lower limbs and central nervous system in workers[J]. Clin Toxicol,2006,44(5):88.
[22] 王强毅,李卫华,李洁斐,等. 低浓度1-溴丙烷对接触者神经系统的影响[J]. 环境与职业医学,2007,24(2):4. [23] 李卫华,王强毅,市原学. 1-溴丙烷对接触工人神经毒性的剂量-效应关系[J]. 中华劳动卫生职业病杂志,2010,28(7):488-493. [24] 李卫华,周志俊,王强毅. 职业接触1-溴丙烷对女工神经系统和血液及生化学的影响[J]. 中华劳动卫生职业病杂志,2010,28(5):339-344. [25] Li W,Shibata E,Zhou Z,et al. Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane[J]. J Occup Environ Med,2010,52(8):769-777.
[26] 王强毅,李卫华,丁训诚,等. 谷胱甘肽S转移酶基因多态性对1-溴丙烷接触者神经传导速度的影响[J]. 环境与职业医学,2007,24(5):4. [27] Yoshida Y,Liu J,Nakano Y. 1-BP inhibits NF-kB activity and Bcl-xL expression in astrocytes in vitro and reduces Bcl-xL expression in the brains of rats in vivo[J]. Neurotoxicology,2007,28(2):381-386.
[28] Yoshida Y,Nakano Y,Ueno S,et al. Effects of 1-bromopropane,a substitute for chlorofluorocarbons,on BDNF expression[J]. Int Immunopharmacol,2009,9(4):433-438.
[29] Ichihara G,Kitoh J,Yu X Z,et al. 1-bromopropane,an alternative to ozone layer depleting solvents,is dose-dependently neurotoxic to rats in long-term inhalation exposure[J]. Toxicol Sci,2000,55(1):116-123.
[30] Suda M,Honma T,Miyagawa M,et al. Alteration of brain levels of neurotransmitters and amino acids in male F344 rats induced by three-week repeated inhalation exposure to 1-bromopropane[J]. Ind Health,2008,46(4):348-359.
[31] Wang H L,Ichihara G,Ito H,et al. Dose-dependent biochemical changes in rat central nervous system after 12-week exposure to 1-bromopropane[J]. Neurotoxicology,2003,24(2):199-206.
[32] Wang H L,Ichihara G,Ito H,et al. Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for seven days[J]. Toxicol Sci,2002,67(1):114-120.
[33] 李卫华,王海兰,Ichihara Gaku,等. F344/NSIc与Wistar NWN大鼠对1-溴丙烷引发毒效应的比较研究[J]. 实验动物与比较医学,2010,30(2):105-108. [34] Zhong Z,Zeng T,Xie K,et al. Elevation of 4-hydroxynonenal and malondialdehyde modified protein levels in cerebral cortex with cognitive dysfunction in rats exposed to 1-bromopropane[J]. Toxicology,2013,306:16-23.
[35] 宋向荣,王海兰,黄芬,等. 1-溴丙烷吸入对大鼠脑皮质神经丝蛋白表达的影响[J]. 中国职业医学,2009,36(1):4. [36] Subramanian K,Mohideen S S,Suzumura A,et al. Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum[J]. Toxicology,2012,302(1):18-24.
[37] Mohideen S S,Ichihara G,Ichihara S,et al. Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain[J]. Toxicology,2011,285(1-2):67-71.
[38] Ueno S,Yoshida Y,Fueta Y,et al. Changes in the function of the inhibitory neurotransmitter system in the rat brain following subchronic inhalation exposure to 1-bromopropane[J]. Neurotoxicology,2007,28(2):415-420.
[39] Fueta Y,Ishidao T,Ueno S,et al. New approach to risk assessment of central neurotoxicity induced by 1-bromopropane using animal models[J]. Neurotoxicology,2007,28(2):270-273.
[40] Zhang L,Nagai T,Yamada K,et al. Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats[J]. Toxicology,2013,304:76-82.
[41] Huang Z,Ichihara S,Oikawa S,et al. Proteomic identification of carbonylated proteins in F344 rat hippocampus after 1-bromopropane exposure[J]. Toxicol Appl Pharmacol,2012,263(1):44-52.
[42] Huang Z,Ichihara S,Oikawa S,et al. Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane[J]. Toxicol Appl Pharmacol,2011,257(1):93-101.
[43] Ichihara G,Mohideen S S,Ichihara S,et al. Changes in neurotransmitter receptor expression levels in rat brain after 4-week exposure to 1-bromopropane[J]. Neurotoxicology,2009,30(6):1078-1083.
计量
- 文章访问数: 300
- HTML全文浏览量: 36
- PDF下载量: 42
下载:
