Abstract: Objective To study occupational hazards in isocyanate production process and introduce the relevant protective measures. Methods The major occupational hazards and protective measures were analyzed through introduction of production technology of isocyanate phosgenation method,combined with the field survey. Results There were occupational hazards,such as phosgene,chlorine,carbon monoxide and isocyanate in isocyanate production process. In order to avoid occupational hazards accident,scientific and effective protective measures should be performed in the aspects of engineering protection,personal protection and emergency rescue. Conclusion The analysis of occupational hazards and protective measures in production of isocyanate provide technical base for protection against occupational hazards.