Abstract: Objective This article aims at understanding epidemiological and clinical features of occupational medicamentosa-like dermatitis induced by trichloroethylene(OMLDT),and provide orientation for further clinical studies and prophylaxis. Methods OMLDT cases that occurred in from 2006 to 2011 in Shenzhen were surveyed. Results There were 84 OMLDT cases diagnosed in Shenzhen from 2006 to 2011. With the time going, the number of diagnosed cases seemed decreasing, but there were no statistical significance from year to year. More cases were diagnosed in April, July and August and fewer cases in February (usually Chinese new year festivals). The major clinical manifestations were exanthemata, pyrexia and hepatic lesion. The cases received the hormonotherapy for 83 ±39 days. 57% cases were reported with nosocomial infection and complications. The recovery rate was 96.4%, with fatality 3.6%. Conclusion The fatality of occupational trichloroethylene medicamentosa-like dermatitis is decreasing and high nosocomial infection and complication rates pose as the major causes leading to the death.