乳酸脱氢酶在急性氰化物中毒诊断中的临床意义

详细信息

Clinical significance of lactate dehydrogenase in diagnosis of acute hydrogen cyanide poisoning

摘要: 目的分析急性氰化物中毒时血中乳酸脱氢酶的变化,为急性氰化物中毒的诊断分级提供依据。方法选取同一氰化物中毒事故中的6例患者,对其中毒后108 h内的血中乳酸脱氢酶进行分析比较。结果急性氰化物中毒患者的乳酸脱氢酶超过300 U/L以上,恢复较慢;接触反应患者乳酸脱氢酶低于300 U/L,恢复较快。结论提示在临床工作中可检查乳酸脱氢酶指标值,作为临床诊断起点的参考。
- 氰化氢 /
- 乳酸脱氢酶 /
- 中毒 /
- 临床意义
+ English
Abstract: Objective The changes of blood lactate dehydrogenase(LDH) of cyanide poisoning cases were carefully observed to provide the orientation for the diagnosis and grading of cyanide poisoning. Methods A total of 6 cases with accidental hydrogen cyanide poisoning were studied and their time-course changes of blood lactate dehydrogenase were recorded till 108 hours. Results Lactate dehydrogenase level of hydrogen cyanide poisoning patients was above 300 U/L and recovered slowly, while that of exposed persons was less than 300 U/L and recovered rapidly. Conclusion It suggested that the lactic dehydrogenase was useful for the diagnosis at early stage.
- Hydrogen cyanide /
- Lactate dehydrogenase(LDH) /
- Poisoning /
- Clinical significance

[1]	中华人民共和国卫生部. GBZ 209-2008职业性急性氰化物中毒诊断标准[S]. 北京:中国标准出版社,2008.
[2]	何凤生,王世俊,任引津. 中华职业医学[M]. 北京:人民卫生出版社,1999:679-705.
[3]	Gracia R,Shepherd G. Cyanide poisoning and its treatment[J]. Pharmacotherapy,2004,24(10):1358-1365.
[4]	Lapostolle F,Borron S,Baud F. Increased plasma lactate concentrations are associated with cyanide but not other types of acute poisoning[J]. Clin Toxicol(Phila),2006,44(5):777.
[5]	朱晓莉,王涤,翟明芬,等. 急性氰化物中毒36例临床分析[J]. 中国职业医学,2011,2(1):41-43.
[6]	董磊,张晓鹏,陈薇. 心肌损伤标志物研究进展[J]. 科技导报,2008,26(3):81-85.
[7]	吴英. 脑损伤患者血清肌酸激酶及乳酸脱氢酶同工酶的分析与临床应用[J]. 西南师范大学学报:自然科学版,2008(6):114.