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JIANG Wei, CHEN Xiang, MIAO Wen-bin, ZHU Hong-kun. Chromosome aberration of Chinese hamster lung cells induced by fluorescent brightener[J]. Occupational Health and Emergency Rescue, 2013, 31(2): 71-73.
Citation: JIANG Wei, CHEN Xiang, MIAO Wen-bin, ZHU Hong-kun. Chromosome aberration of Chinese hamster lung cells induced by fluorescent brightener[J]. Occupational Health and Emergency Rescue, 2013, 31(2): 71-73.
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Chromosome aberration of Chinese hamster lung cells induced by fluorescent brightener

  • Shanghai Entry-exit Inspection and Quarantine Bureau, Shanghai 200135, China

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  • Received Date: January 16, 2013
  • Revised Date: February 27, 2013
    Graphical Abstract
    • Abstract
  • [Objective] Fluorescent brightener is one of chemicals listed in "Classification Chart of Occupational Hazardous" announced by SAWS. In order to understand the mechanism of genetic damage, the chromosome damage induced by fluorescent brightener on CHL (Chinese hamster lung) cells was studied. [Methods] CHL cells were treated with different concentrations of fluorescent brightener 28 in vitro and chromosome aberration of treated CHL cells was detected. [Results] Under the testing conditions with an exogenous source of metabolic activation system(S9), there was no significant increasing percentage of cells with structural aberrations in treated groups, compared with negative control. [Conclusion] Fluorescent brightener 28 may not induce chromosome damage in cultured mammalian cells.
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    • References (9)
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