Correlation between lymphocyte subsets and liver dysfunction among patients with dermatitis medicamentosa-like of Trichloroethylene

[Objective] The correlation between lymphocyte subsets and liver dysfunction among patients with dermatitis medicamentosa-like of trichloroethylene was evaluated to explore the pathogenesis of this disease. [Methods] A total of 32 patients were studied. Their lymphocyte subsets and liver function at hospitalization time were analyzed. [Results] The variation of lymphocyte subsets among the patients with different types of skin rashes had no significant difference (P>0.05); compared with reference values, the percentage of patients' mature T lymphocyte (CD3⁺) and CD8⁺T lymphocyte (CD3⁺CD8⁺) both increased significantly; the percentage of CD4⁺ T lymphocyte (CD3⁺ CD4⁺), NK cell(CD3-CD₁₆₊₅₆⁺),and B Lymphocyte subsets(CD19⁺) and CD4⁺/CD8⁺ all decreased significantly (P<0.01). There was a positive linear correlation between GTP and T lymphocyte (CD3⁺) and negative linear correlation between lymphocytes or CD3⁺ cells and cholinesterase or albumin. [Conclusion] The patients with dermatitis medicamentosa-like of trichloroethylene had disorder both of cellular and humoral immunity systems; there existed relationship between the liver dysfunction and this cellular immune system disorder.